BioHit Monoclonal Antibodies to Human Spectrins

Biohit Monoclonal Antibodies (MAbs) are efficient tools for research in the area of cellular pathology, neurobiology and oncology as well as in research of human gastric biomarkers. Biohit MAbs are all produced in mouse, and they have been purified after production. They are all highly specific to their antigens and are applicable in immunohistochemistry, immunoprecipitation and Western blotting.

MAbs to Human Spectrins

Erythroid spectrins, some other proteins of erythroid cytoskeleton, and the transmembrane protein band 3 are highly specific for erythrocytes and their progenitors. They are more reliable markers for erythroid differentiation than Glycophorin A, the commonly used marker for erythroid differentiation, because Glycophorin A is expressed also in many cell lines otherwise exhibiting mainly megacaryotic charasteristics. Both erythroid alpha-spectrin(11) and erythroid ß-spectrin monoclonal antobodies can be used for example in identification of erythroid leukemias.