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Biohit Monoclonal Antibodies (MAbs) are efficient tools for research in the area of cellular pathology, neurobiology and oncology as well as in research of human gastric biomarkers. Biohit MAbs are all produced in vitro, and they have been purified after production. They are all highly specific to their antigens and are applicable in immunohistochemistry, immunoprecipitation and Western blotting. With Biohit MAbs the researcher can produce good images for scientific publications.
MAbs to Human Gastric Biomarkers
Gastrin-17: Amidated gastrin-17 is a biologically and physiologically important molecule among the family of the gastrin peptides. Amidated gastrin-17 is the most powerful gastrin peptide in the feedback control mechanism of the acid secretion and output from the parietal cells in the gastric corpus. This peptide is solely synthetized and secreted into the circulation by the so called G cells (“gastrin cells”) in the gastric antrum.
Pepsinogen I: Pepsinogen I is a group of precursor molecules for pepsin. These proteins are solely synthetized and secreted into gastric lumen by chief (pepsin) cells and mucous neck cells in the gastric corpus (oxyntic mucosa).
Pepsinogen II: Pepsinogen II is a group of precursor molecules for pepsin. These proteins are secreted into the gastric lumen by the pyloric glands of the gastric antrum and also by the chief and neck cells of the gastric corpus (oxyntic mucosa). Negative immunohistochemical reaction for pepsinogen I (right) but positive reaction for pepsinogen II (left) is a typical sign of the antral mucosa and, in the presence of atrophic gastritis, this staining pattern indicates that the positive glands and cells are metaplastic and “pyloric” in differentiation (so called pseudopyloric metaplasia).
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Item Name |
List Price |
BLD Price |
Qty |
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| BIOCP242 |
BioHit Gastrin 17, G52C7.1, Purified, 100 µg |
$690.00 |
$655.50 |
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| BIOCP240 |
BioHit Pepsinogen I, 4C6.1, Purified, 100 µg |
$575.00 |
$546.25 |
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| BIOCP241 |
BioHit Pepsinogen II, L10CC10, Purified, 100 µg |
$575.00 |
$546.25 |
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